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USC-OGP 2-DE database
Two-dimensional polyacrylamide gel electrophoresis database
USC-OGP 2-DE database
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Searching in 'USC-OGP 2-DE database' for entry
matching:
Q9UMS4
USC-OGP 2-DE database
:
Q9UMS4
Q9UMS4
General information about the entry
View entry in simple text format
Entry name
PRP19_HUMAN
Primary accession number
Q9UMS4
integrated into USC-OGP 2-DE database on
January 17, 2017 (release 1)
2D Annotations were last modified on
January 17, 2017 (version 1)
General Annotations were last modified on
April 5, 2017 (version 2)
Name and origin of the protein
Description
RecName: Full=Pre-mRNA-processing factor 19 {ECO:0000305}; EC=2.3.2.27 {ECO:0000269|PubMed:11435423}; AltName: Full=Nuclear matrix protein 200 {ECO:0000303|PubMed:11082287}; AltName: Full=PRP19/PSO4 homolog {ECO:0000303|PubMed:12960389}; Short=hPso4 {ECO:0000303|PubMed:12960389}; AltName: Full=RING-type E3 ubiquitin transferase PRP19 {ECO:0000305}; AltName: Full=Senescence evasion factor {ECO:0000303|PubMed:16332694};.
Gene name
Name=PRPF19
{ECO:0000312|HGNC:HGNC:17896}
Synonyms=NMP200 {ECO:0000303|PubMed:11082287}, PRP19 {ECO:0000303|PubMed:11435423}, SNEV {ECO:0000303|PubMed:16332694}
Annotated species
Homo sapiens (Human) [TaxID:
9606
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]
2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein
UVEAL_MELANOMA_3-10
{UVEAL MELANOMA 3-10}
Homo sapiens (Human)
map experimental info
UVEAL_MELANOMA_3-10
MAP LOCATIONS:
SPOT OGP-1150
:
pI=6.41; Mw=55186
SPOT OGP-1312
:
pI=5.04; Mw=21529
SPOT OGP-1318
:
pI=5.55; Mw=19701
SPOT OGP-1331
:
pI=5.13; Mw=16684
SPOT OGP-1335
:
pI=5.02; Mw=16085
Cross-references
UniProtKB/Swiss-Prot
Q9UMS4; PRP19_HUMAN.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
0.0
Entry name
PRP19_HUMAN
Primary accession number
Q9UMS4
Sequence was last modified on
May 1, 2000 (version 1)
Annotations were last modified on
March 15, 2017 (version 154)
Name and origin of the protein
Description
RecName: Full=Pre-mRNA-processing factor 19 {ECO:0000305}; EC=2.3.2.27 {ECO:0000269|PubMed:11435423}; AltName: Full=Nuclear matrix protein 200 {ECO:0000303|PubMed:11082287}; AltName: Full=PRP19/PSO4 homolog {ECO:0000303|PubMed:12960389}; Short=hPso4 {ECO:0000303|PubMed:12960389}; AltName: Full=RING-type E3 ubiquitin transferase PRP19 {ECO:0000305}; AltName: Full=Senescence evasion factor {ECO:0000303|PubMed:16332694};
Gene name
Name=PRPF19
{ECO:0000312|HGNC:HGNC:17896}
Synonyms=NMP200 {ECO:0000303|PubMed:11082287}, PRP19 {ECO:0000303|PubMed:11435423}, SNEV {ECO:0000303|PubMed:16332694}
Encoded on
Name=PRPF19 {ECO:0000312|HGNC:HGNC:17896}; Synonyms=NMP200 {ECO:0000303|PubMed:11082287}, PRP19 {ECO:0000303|PubMed:11435423}, SNEV {ECO:0000303|PubMed:16332694
Keywords
3D-structure
;
Acetylation
;
Complete proteome
;
Cytoplasm
;
Cytoskeleton
;
Direct protein sequencing
;
DNA damage
;
DNA repair
;
Lipid droplet
;
mRNA processing
;
mRNA splicing
;
Nucleus
;
Reference proteome
;
Repeat
;
Spliceosome
;
Transferase
;
Ubl conjugation pathway
;
WD repeat
.
Copyright
Copyrighted by the UniProt Consortium, see
http://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
AJ131186; CAB51857.1
; -; mRNA
EMBL
BC008719; AAH08719.1
; -; mRNA
EMBL
BC018665; AAH18665.1
; -; mRNA
EMBL
BC018698; AAH18698.1
; -; mRNA
CCDS
CCDS7995.1; -
; .
RefSeq
NP_055317.1; NM_014502.4
; .
UniGene
Hs.502705; -
; .
PDB
4LG8; X-ray
; 1.89 A; A=169-504
PDBsum
4LG8; -
; .
ProteinModelPortal
Q9UMS4; -
; .
SMR
Q9UMS4; -
; .
BioGrid
118151; 173
; .
DIP
DIP-32978N; -
; .
IntAct
Q9UMS4; 42
; .
MINT
MINT-1454442; -
; .
STRING
9606.ENSP00000227524; -
; .
iPTMnet
Q9UMS4; -
; .
PhosphoSitePlus
Q9UMS4; -
; .
SwissPalm
Q9UMS4; -
; .
BioMuta
PRPF19; -
; .
DMDM
55976619; -
; .
REPRODUCTION-2DPAGE
IPI00004968; -
; .
SWISS-2DPAGE
Q9UMS4; -
; .
EPD
Q9UMS4; -
; .
MaxQB
Q9UMS4; -
; .
PaxDb
Q9UMS4; -
; .
PeptideAtlas
Q9UMS4; -
; .
PRIDE
Q9UMS4; -
; .
DNASU
27339; -
; .
Ensembl
ENST00000227524; ENSP00000227524
; ENSG00000110107; .
GeneID
27339; -
; .
KEGG
hsa:27339; -
; .
UCSC
uc001nqf.4; human
; .
CTD
27339; -
; .
DisGeNET
27339; -
; .
GeneCards
PRPF19; -
; .
HGNC
HGNC:17896; PRPF19
; .
HPA
CAB012448; -
; .
HPA
HPA038051; -
; .
HPA
HPA059070; -
; .
MIM
608330; gene
; .
neXtProt
NX_Q9UMS4; -
; .
OpenTargets
ENSG00000110107; -
; .
PharmGKB
PA134941355; -
; .
eggNOG
KOG0289; Eukaryota
; .
eggNOG
ENOG410XPQV; LUCA
; .
GeneTree
ENSGT00860000133707; -
; .
HOGENOM
HOG000177308; -
; .
HOVERGEN
HBG053697; -
; .
InParanoid
Q9UMS4; -
; .
KO
K10599; -
; .
OMA
SEDQYWA; -
; .
OrthoDB
EOG091G05AH; -
; .
PhylomeDB
Q9UMS4; -
; .
TreeFam
TF105919; -
; .
Reactome
R-HSA-6781823; Formation of TC-NER Pre-Incision Complex
; .
Reactome
R-HSA-6781827; Transcription-Coupled Nucleotide Excision Repair (TC-NER)
; .
Reactome
R-HSA-6782135; Dual incision in TC-NER
; .
Reactome
R-HSA-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER
; .
Reactome
R-HSA-72163; mRNA Splicing - Major Pathway
; .
SignaLink
Q9UMS4; -
; .
UniPathway
UPA00143; -
; .
ChiTaRS
PRPF19; human
; .
GeneWiki
PRPF19; -
; .
GenomeRNAi
27339; -
; .
PRO
PR:Q9UMS4; -
; .
Proteomes
UP000005640; Chromosome 11
; .
Bgee
ENSG00000110107; -
; .
CleanEx
HS_PRPF19; -
; .
ExpressionAtlas
Q9UMS4; baseline and differential
; .
Genevisible
Q9UMS4; HS
; .
GO
GO:0071013; C:catalytic step 2 spliceosome
; IDA:UniProtKB; .
GO
GO:0005737; C:cytoplasm
; IDA:MGI; .
GO
GO:0005811; C:lipid particle
; IEA:UniProtKB-SubCell; .
GO
GO:0016020; C:membrane
; IDA:UniProtKB; .
GO
GO:0016607; C:nuclear speck
; IDA:UniProtKB; .
GO
GO:0005654; C:nucleoplasm
; TAS:Reactome; .
GO
GO:0005634; C:nucleus
; IDA:UniProtKB; .
GO
GO:0000974; C:Prp19 complex
; IDA:UniProtKB; .
GO
GO:0035861; C:site of double-strand break
; IDA:UniProtKB; .
GO
GO:0005819; C:spindle
; IEA:UniProtKB-SubCell; .
GO
GO:0071006; C:U2-type catalytic step 1 spliceosome
; IBA:GO_Central; .
GO
GO:0042802; F:identical protein binding
; IPI:BHF-UCL; .
GO
GO:0061630; F:ubiquitin protein ligase activity
; IMP:UniProtKB; .
GO
GO:0034450; F:ubiquitin-ubiquitin ligase activity
; IDA:MGI; .
GO
GO:0034613; P:cellular protein localization
; IMP:UniProtKB; .
GO
GO:0006303; P:double-strand break repair via nonhomologous end joining
; IMP:UniProtKB; .
GO
GO:0000349; P:generation of catalytic spliceosome for first transesterification step
; IBA:GO_Central; .
GO
GO:0001833; P:inner cell mass cell proliferation
; IEA:Ensembl; .
GO
GO:0008610; P:lipid biosynthetic process
; IEA:Ensembl; .
GO
GO:0000398; P:mRNA splicing
; via spliceosome; IDA:UniProtKB
GO
GO:0045665; P:negative regulation of neuron differentiation
; IEA:Ensembl; .
GO
GO:0048711; P:positive regulation of astrocyte differentiation
; IEA:Ensembl; .
GO
GO:0048026; P:positive regulation of mRNA splicing
; via spliceosome; IEA:Ensembl
GO
GO:0010498; P:proteasomal protein catabolic process
; IMP:UniProtKB; .
GO
GO:0070534; P:protein K63-linked ubiquitination
; IMP:UniProtKB; .
GO
GO:0000209; P:protein polyubiquitination
; IDA:MGI; .
GO
GO:0072422; P:signal transduction involved in DNA damage checkpoint
; IMP:UniProtKB; .
GO
GO:0000245; P:spliceosomal complex assembly
; IMP:BHF-UCL; .
GO
GO:0000244; P:spliceosomal tri-snRNP complex assembly
; IDA:UniProtKB; .
GO
GO:0006283; P:transcription-coupled nucleotide-excision repair
; TAS:Reactome; .
Gene3D
2.130.10.10; -
; 1; .
Gene3D
3.30.40.10; -
; 1; .
InterPro
IPR020472; G-protein_beta_WD-40_rep
; .
InterPro
IPR013915; Pre-mRNA_splic_Prp19
; .
InterPro
IPR000772; Ricin_B_lectin
; .
InterPro
IPR003613; Ubox_domain
; .
InterPro
IPR015943; WD40/YVTN_repeat-like_dom
; .
InterPro
IPR001680; WD40_repeat
; .
InterPro
IPR019775; WD40_repeat_CS
; .
InterPro
IPR017986; WD40_repeat_dom
; .
InterPro
IPR013083; Znf_RING/FYVE/PHD
; .
Pfam
PF08606; Prp19
; 1; .
Pfam
PF04564; U-box
; 1; .
Pfam
PF00400; WD40
; 5; .
PRINTS
PR00320; GPROTEINBRPT
; .
SMART
SM00504; Ubox
; 1; .
SMART
SM00320; WD40
; 7; .
SUPFAM
SSF50978; SSF50978
; 1; .
PROSITE
PS51698; U_BOX
; 1; .
PROSITE
PS00678; WD_REPEATS_1
; 1; .
PROSITE
PS50082; WD_REPEATS_2
; 4; .
PROSITE
PS50294; WD_REPEATS_REGION
; 1; .
Gateways to other related servers
The World-2DPAGE Constellation
- Entry point to the world-wide 2-DPAGE resources.
World-2DPAGE Repository
- A public repository for gel-based proteomics data linked to protein identification published in the literature.
World-2DPAGE Portal
- A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
SWISS-2DPAGE
- The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
ExPASy
- The resources web server of the
Swiss Institute of Bioinformatics
Database constructed and maintained by
Angel Garcia
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
ExPASy web server
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